Keratinocyte Growth Regulation in Defined Organotypic Cultures Through IL-1-Induced Keratinocyte Growth Factor Expression in Resting Fibroblasts
نویسندگان
چکیده
منابع مشابه
Regulation of keratinocyte growth factor gene expression in human skin fibroblasts.
Human keratinocyte growth factor (KGF) is a recently identified mitogen for epithelial cells produced by normal stromal fibroblasts. KGF has been shown to stimulate keratinocyte migration and promote re-epithelialization of skin suggesting a critical role for KGF in wound healing. To understand how KGF might be regulated during wound healing, we examined the ability of the pro-inflammatory cyto...
متن کاملEffect of One Time Irradiation of Uvb Non Keratinocyte Growth Factor Gene Expression in Mice
Purpose: Skin is continuously exposed to many hazardous environmental factors such as ultraviolet radiation (UV). Many investigations have been shown to cause skin damages. The aim of present research was to study the effect of a single time of UVB radiation on the expression pattern of keratinocyte growth factor (KGF) gene in mice. Materials and Methods: UVB (30 mJ/cm2 and 50 mJ/cm2) were rad...
متن کاملHuman beta defensin-4 and keratinocyte growth factor gene expression in cultured keratinocyte and fibroblasts of burned patients.
PURPOSE To evaluate KGF and human beta defensin-4 (HBD-4) levels produced by dermic fibroblasts and keratinocytes cultivated from burned patients' skin samples. METHODS Keratinocytes and fibroblasts of 10 patients (four major burns, four minor burns and two controls) were primarily cultivated according to standard methods. HBD-4 and KGF genes were analyzed by quantitative PCR. RESULTS In fi...
متن کاملExpression of keratinocyte growth factor in periapical lesions.
The epithelial proliferation associated with inflammatory periapical lesions and with periapical cyst formation represents an interesting but poorly understood pathological change. Keratinocyte growth factor (KGF) is a recently identified growth factor that is produced by stromal fibroblasts and acts specifically to stimulate epithelial growth and differentiation. To investigate its possible ro...
متن کاملRegulation of thymic epithelium by keratinocyte growth factor.
Here we demonstrate that keratinocyte growth factor (KGF) and FGFR2IIIb signaling can affect development and function of thymic epithelium (TE) and that alphabeta-lineage thymocytes contribute to intrathymic levels of KGF. Thymocyte expression of KGF is developmentally regulated, being undetectable in CD3-4-8- thymocytes and expressed at highest levels by mature CD4 or CD8 thymocytes. Exposure ...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 2000
ISSN: 0022-202X
DOI: 10.1046/j.1523-1747.2000.00987.x